McCoy to Kirk: Are you out of your corn-fed mind?
McCoy to Spock: Are you out of your Vulcan mind?
McCoy to Chekov: Are you out of your vodka-soaked mind?
McCoy to Sulu: Are you out of your sword-wielding mind?
McCoy to Scotty: Are you out of your tartan-wearing mind?
McCoy to Uhura: Have you considered an alternative option?